Nexplanon Side Effects: Weight Gain and Depression

Ovarian Cysts. The implant’s label reads: “If follicular development occurs, atresia of the follicle is sometimes delayed, and the follicle may continue to grow beyond the size it would attain in a normal cycle. Generally, these enlarged follicles disappear spontaneously. On rare occasion, surgery may be required.”

Nexplanon Side Effects: Weight gain. This is apt to be a big disappointment for many: average weight gain of those using Nexplanon was 2.8 pounds after one year and 3.7 pounds after two years — high rates that will surely contribute to a creeping increase of weight that may lead to obesity.

Depressed mood. Using Nexplanon may contribute to a depressed mood, and the drug’s label specifically urges that women with a history of depression should be observed carefully.





The side effects that women in clinical trials found most unbearable were bleeding irregularities, emotional instability, weight gain, headache, acne and depression.

Nexplanon side effects post-marketing: Additional side effects were identified during post-approval use of Nexplanon.

Reported voluntarily by women “from a population of uncertain size,” it’s not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Complications related to insertion or removal of the non-radiopaque etonogestrel implant reported include: bruising, slight local irritation, pain or itching, fibrosis at the implant site, paresthesia or paresthesia-like events, scarring and abscess.

Pregnancy, puerperium and perinatal conditions: ectopic pregnancy.

Reproductive system and breast disorders: breast discharge, breast enlargement, ovarian cyst, pruritus genital, vulvovaginal discomfort.

General disorders and administration site conditions: edema, fatigue, implant site reaction, pyrexia.

Infections and infestations: rhinitis, urinary tract infection.

Psychiatric disorders: anxiety, insomnia, libido decreased.

Nervous system disorders: convulsions, migraine, somnolence.





Renal and urinary disorders: dysuria.

Metabolism and nutrition disorders: increased appetite.

Musculoskeletal and connective tissue disorders: arthralgia, musculoskeletal pain, myalgia.

Gastrointestinal disorders: constipation, diarrhea, flatulence, vomiting.

Investigations: clinically relevant rise in blood pressure, weight decreased.

Skin and subcutaneous tissue disorders: (aggravation of) angioedema and/or aggravation of hereditary angioedema, alopecia, chloasma, hypertrichosis, pruritus, rash, seborrhea, urticaria.

Vascular disorders: hot flush.

Nexplanon Side Effects: Weight Gain and Depression posted 18 February 2012. Last update on 18 February 2012.

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