Votrient Side Effects: Weight Loss, Nausea, High Blood Pressure. Last April, the Food and Drug Administration (FDA) approved the use of the drug Votrient (generic name: pazopanib) to treat “patients with advanced soft tissue sarcoma who have previously received chemotherapy”.
Reports, such as a Daily Mail story, claim that Votrient has less burdensome side effects but it is still very important to familiarize ourselves with what these side effects are.
According to the FDA’s press release the most common Votrient side effects are as follows: fatigue, diarrhea, nausea, weight loss, high blood pressure, decreased appetite, vomiting, tumor and muscle pain, hair color changes, headache, a distorted sense of taste, shortness of breath, and skin discoloration.
>> VOTRIENT SIDE EFFECTS RELATED POST: Aromasin Side Effects, Adverse Risks, and Health Benefits
As for less common but more serious Votrient side effects, the medication guide issued by the drug manufacturer, GlaxoSmithKline, and approved by the FDA mentions the following:
Now, the most important thing that you should know about Votrient side effects according to the medication guide issued by its manufacturer is that VOTRIENT can cause serious liver problems which can lead to death.
That’s why your healthcare provider should conduct blood tests to check your liver before you start medication and while you are taking VOTRIENT. A patient should also tell his/her healthcare provider immediately if he/she has any of the following signs of liver problems during treatment with VOTRIENT:
If you do develop liver problems during treatment, your healthcare provider may need to prescribe a lower dose of VOTRIENT for you or tell you to stop taking the drug altogether.
How should you take Votrient? Here’s what the medication guide advises you to do:
Is Votrient effective? In its news release announcing its approval of Votrient, the FDA has this to say about the effectiveness of the drug for patients with advanced soft tissue sarcoma:
The safety and effectiveness of Votrient was evaluated in a single clinical study in 369 patients with advanced soft tissue sarcoma who had received prior chemotherapy. Patients were randomly selected to receive Votrient or a placebo. The study was designed to measure the length of time a patient lived without the cancer progressing (progression-free survival). The disease did not progress for a median of 4.6 months for patients receiving Votrient, compared with 1.6 months for those receiving the placebo.
Votrient Side Effects: Weight Loss, Nausea, High Blood Pressure posted 12 June 2012. Last update on 27 April 2017.
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